Research Network Natural Products against Neglected Diseases - ResNet NPND

Green medicine for the poorest of the poor

Joint publications of ResNet NPND members - Under construction

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2014

Thao NP, No JH, Yang GS, Byun SY, Goon JH, Luyen BTT, Cuong NX, Nam NH, Minh CV, Schmidt TJ, Kang JS, Kim YH. Secondary Metabolites from Vietnamese Marine Invertebrates with Activity Against Trypanosoma brucei and T. cruzi. Molecules 19, 7869-7880 (2014). doi:10.3390/molecules19067869

Pinto EG, Santos IO, Schmidt TJ, Borborema SET, Ferreira VF, da Rocha DR, Tempone AG. Potential of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against Leishmania infantum: Biological activity and structure-activity relationships. PLoS ONE 9(8): e105127. doi:10.1371/journal.pone.0105127

Althaus JB, Kaiser M, Brun R, Schmidt TJ. Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents. Molecules 19, 6428-6438 (2014). doi:10.3390/molecules19056428  

Althaus JB, Jerz G, Winterhalter P, Kaiser M, Brun R, Schmidt TJ. Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloyl-cyclovirobuxeine-B as main constituent active against Plasmodium falciparum. Molecules 19, 6184-6201 (2014). doi:10.3390/molecules19056184  

Schmidt TJ (Guest Editor). Topical Collection "Natural Products as Leads or Drugs against Neglected Tropical Diseases". Molecules, MDPI, Basel, 2014; ISSN 1420-3049;  

http://www.mdpi.com/journal/molecules/special_issues/natural_products_against_NTD

Schmidt TJ, Da Costa FB, Lopes NP, Kaiser M, Brun R. In silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense. Antimicrob. Agents Chemother. 58, 325-332 (2014).  

Montrieux E, García M, Perera W, Maes L, Cos P, Monzote L. In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis. Parasitol Res 2014;113(8):2925-32.

Monzote L, García M, Scull R, Cuellar A, Setzer WN. Antileishmanial activity of the essential oil from Bixa orellana. Phytother Res 2014;28(5):753-8.

2013

Adebajo AC, Odediran SA, Nneji CM, Iwalewa EO, Rukunga GM, Aladesanmi AJ, Gathirwa JW, Ademowo OG, Olugbade TA, Schmidt TJ, Verspohl EJ. Evaluation of Ethnomedical Claims II: Antimalarial Activities of Gongronema latifolium Root and Stem. Journal of Herbs, Spices & Medicinal Plants, 19, 97–118 (2013)  

Adebajo, A.C., Ayoola, M.D., Odediran, S.A., Aladesanmi, A.J., Schmidt, T.J., Verspohl, E.J. Evaluation of ethnomedical claim III: anti-hyperglycemic activities of Gongronema latifolium root and stem. J. Diabetes. 5, 336-343 (2013).  

Harel, D., Schepmann, D., Prinz, H., Brun, R., Schmidt, T.J., Wünsch B. Enantioselective synthesis of encecaline-derived potent antimalarial agents. Org. Biomol. Chem. 11, 7342-7349 (2013).  

Harel, D., Schepmann, D., Prinz, H., Brun, R., Schmidt, T.J., Wünsch B. Natural product derived antiprotozoal agents: Synthesis, biological evaluation and structure-activity relationships of novel chromene and chromane derivatives. J. Med. Chem. 56, 7442-7448 (2013).  

Arakawa, N.S., Gobbo-Neto, L., Ambrosio, S.R., Ausech Antonucci, G. Vilela Sampaio, S. Tallarico Pupo, M., Said, S., Schmidt, T.J., Da Costa, F.B. Unusual biotransformation products of the sesquiterpene lactone budlein A by Aspergillus species. Phytochemistry 96, 92-100 (2013).  

Schomburg, C. Schuehly, W., Da Costa, F.B., Klempnauer, K.H., Schmidt, T.J. Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: Structure-activity relationships. Eur. J. Med. Chem. 63, 313-320 (2013).  

Godinho, V.M., Furbino, L.E., Santiago, I.F., Pellizzari, F.M., Yokoya, N.S., Pupo, D., Alves, T.M.A., Junior P.A.S., Romanha, A.J., Zani, C.L., Cantrell, C.L., Rosa, C.A., Rosa, L.H. Diversity and bioprospecting of fungal communities associated with endemic and cold-adapted macroalgae in Antarctica. The ISME Journal 7, 1434–1451 (2013).

Monzote L, García M, Pastor J, Gil L, Scull R, Maes L, Cos P, Gille L. Essential oil from Chenopodium ambrosioides and main components: Activity against Leishmania, their mitochondria and other microorganisms. Exp Parasitol. 2013;136C:20-26.

2012

Schmidt, T.J., Rzeppa, S., Kaiser, M., Brun, R. Larrea tridentata – Absolute configuration of its epoxylignans and investigations on its antiprotozoal activity. Phytochem. Lett., 5 632–638 (2012).  

Schmidt, T.J.; Khalid, S.A.; Romanha, A.J.; Alves, T.M.A.; Biavatti, M.W.; Brun, R.; Da Costa, F.B.; de Castro, S.L.; Ferreira, V.F.; de Lacerda, M.V.G.; Lago, J.H.G.; Leon, L.L.; Lopes, N.P.; das Neves Amorim, R.C.; Niehues, M.; Ogungbe, I.V.; Pohlit, A.M.; Scotti, M.T.; Setzer, W.N.; Soeiro, M. de N.C.; Steindel, M.; Tempone, A.G.
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases – Part I. Current Med. Chem. 19, 2128-2175 (2012).

Schmidt, T.J.; Khalid, S.A.; Romanha, A.J.; Alves, T.M.A.; Biavatti, M.W.; Brun, R.; Da Costa, F.B.; de Castro, S.L.; Ferreira, V.F.; de Lacerda, M.V.G.; Lago, J.H.G.; Leon, L.L.; Lopes, N.P.; das Neves Amorim, R.C.; Niehues, M.; Ogungbe, I.V.; Pohlit, A.M.; Scotti, M.T.; Setzer, W.N.; Soeiro, M. de N.C.; Steindel, M.; Tempone, A.G.
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases – Part II. Current Med. Chem. 19, 2176-2228 (2012).

Gökbulut, A., Kaiser, M., Brun, R. Sarer, E., Schmidt, T.J. 9beta-Hydroxyparthenolide esters from Inula montbretiana DC. and their antiprotozoal activity. Planta Med. 78, 225-229 (2012).  

Santiago, I.F., Alves, T.M.A., Rabello, A., Junior P.A.S., Romanha, A.J., Zani, C.L., Rosa, C.A., Rosa, L.H. Leishmanicidal and antitumoral activities of endophytic fungiassociated with the Antarctic angiosperms Deschampsia antarctica Desv. and Colobanthus quitensis (Kunth) Bartl. Extremophiles 16, 95–103 (2012).

Grecco, S.S., Reimão, J.Q., Tempone, A.G., Sartorelli, P., Cunha, R.L.O.R., Romoff, P., Ferreira, M.J.P., Fávero, O.A., Lago, J.H.G. In vitro antileishmanial and antitrypanosomal activities of flavanones from Baccharis retusa DC. (Asteraceae). . Exper. Parasitol. 130, 141–145 (2012).

Morais, T.R., Romoff, P., Fávero, O.A., Reimão, J.Q., Lourenço, W.C., Tempone, A.G., Hristov, A.D., Di Santi, S.M., Lago, J.H.G., Sartorelli, P., Ferreira, M.J.P. Anti-malarial, anti-trypanosomal, and anti-leishmanial activities of jacaranone isolated from Pentacalia desiderabilis (Vell.) Cuatrec. (Asteraceae). Parasitol. Res. 110, 95-101 (2012).

de Oliveira, A. Mesquita, J.T., Tempone A.G., Lago, J.H.G., Guimarães, E.F., Kato, M.J. Leishmanicidal activity of an alkenylphenol from Piper malacophyllum is related to plasma membrane disruption. Exper. Parasitol. 132 383–387 (2012).

Sartorelli, P., Santana, J.S, Guadagnin, R.C, Lago, J.H.G, Pinto, E.G., Tempone, A.G., Stefani, H.A., Soares, M.G., da Silva, A.M. In vitro trypanocidal evaluationof pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae). Quim. Nova, 35, 743-747 (2012).

Monzote L, Cuesta-Rubio O, Campo M, Márquez I, Fraga J, Pérez K, Kerstens M, Maes L, Cos P. In vitro antimicrobial assessment of Cuban propolis extracts. Mem Inst Oswaldo Cruz 2012;107(8):978-84

Monzote L, Hill GM, Cuellar A, Scull R, Setzer WN. Chemical composition and anti-proliferative properties of Bursera graveolens essential oil. Nat Prod Commun. 2012;7(11):1531-4.
Monzote L, Alarcón O, Setzer W. Antiprotozoal activity of essential oils: a brief review from literature. Agriculturae Conspectus Scientificus 2012;77(4):167-75.
2011

Harel, D., Khalid, S. A., Kaiser, M., Brun, R., Wünsch, B., Schmidt, T.J., Encecalol angelate, an unstable chromene from Ageratum conyzoides L.: Total Synthesis and Investigation of its Antiprotozoal Activity. J. Ethnopharmacol. 137, 620-625 (2011).  

Maas, M., Hensel, A., da Costa, F.B., Brun, R., Kaiser, M., Schmidt, T.J. An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatum. Phytochemistry 72, 635-644 (2011).  

Schmidt, T.J., Kaiser, M., Brun, R. Complete structural assignment of Serratol, a cembrane type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity. Planta Med. 77, 849-850 (2011).  

Eberle, C., Lauber, B.S., Fankhauser, D., Kaiser, M., Brun, R., Krauth-Siegel, R.L., Diederich, F. Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities. ChemMedChem 6, 292 – 301 (2011).

Corrêa, D.S., Tempone, A.G., Reimão, J.Q., Taniwaki, N.N., Romoff, P., Fávero, O.A., Sartorelli, P., Mecchi, M.C., Lago, J.H.G. Anti-leishmanial and anti-trypanosomal potential of polygodial isolated from stem barks of Drimys brasiliensis Miers (Winteraceae). Parasitol. Res. 109, 231-236 (2011).

Monzote L, Nance MR, García M, Scull R, Setzer WN. Comparative chemical, cytotoxicity and antileishmanial properties of essential oils from Chenopodium ambrosioides. Nat Prod Commun 2011;6(2):281-6.

Monzote L, Cuesta-Rubio O, Matheeussen A, Van Assche T, Maes L, Cos P. Antimicrobial evaluation of the polyisoprenylated benzophenones nemorosone and guttiferone A. Pythoter Res 2011; 25(3):458-62.